长期致力于血栓形成的细胞与分子机制研究。在二硫键异构酶家族对血栓形成主要蛋白的氧化还原调控网络机制和凝血蛋白的生物学功能等方面取得了一批成果。共发表 SCI 论文20余篇，包括 Nature Communications、J Exp Med、Blood、J Thromb Haemost 等。多次在血栓与止血相关国际会议作大会报告，研究受国家自然科学基金面上项目、自然科学基金青年项目、国家血液系统疾病临床医学等研究项目资助。目前担任国际血栓与止血学会科学与标准化委员会（ISTH-SSC）共同主席。曾获苏州科医学会医学科技奖二等奖、苏州市自然科学学术论文一等奖、国际血栓与止血学会议（ISTH）“青年研究者奖”等。
1. 血栓形成的整合机制及抗血栓药物新靶点研发
2. 凝血系统的生理与病理作用及机制
3. 血小板活化机制
1. 国家自然科学基金-面上项目：二硫键异构酶PDIr负性调控动脉血栓形成的作用与机制（82570181），在研，2026.01-2029.12
2. 国家自然科学基金-面上项目：二硫键异构酶ERp72调控静脉血栓形成的作用与机制（82270136），在研，2023.01-2026.12
3. 国家自然科学基金-面上项目：血浆高分子量激肽原在宿主应答革兰氏阴性细菌感染中的新功能与机制（31970890），结题，2020.01-2023.12
4. 国家血液系统疾病临床医学研究中心转化研究开放课题：二硫键异构酶在CAR-T疗法介导凝血异常中的转化研究（2020WSA04），结题，2020.07-2023.06
5. 国家自然科学基金-青年项目：活化型高分子激肽原抑制内皮祖细胞活性在关节炎动脉粥样硬化发展中的作用（81301534），结题
6. 苏州市科技计划项目：二硫键异构酶PDI调控内质网应激与VLDL组装分泌在肝脂稳态中作用的临床应用研究（SKJY2021043），结题，2021.07.01-2024.06.30
1. Aizhen Yang*#, Yaqiong Zhang*, Yaowei Sun, Miao Jiang, Yi Lu, Yue Han, Depei Wu, Zhipu Luo#, Yi Wu#. Thiol isomerase ERp46 catalyzes the disulfide formation of coagulation factor XII enhancing its activity. J Thromb Haemost. 2025 Nov 4:S1538-7836(25)00716-0.
2. Xiaoying Wang*, Aizhen Yang*, Shuyi Huang, Zhenzhen Zhao, Futian Ma, Yi Lu, Yujie Guo, Yan Wang, Yi Wu#, Jingyu Zhang#. Novel p.C252G and p.C280X mutations in EGF-1 domain of thrombomodulin lead to a thrombosis-bleeding syndrome. J Thromb Haemost. 2025 May 23:S1538-7836(25)00332-0.
3. Xiaofeng Yan*, Yishan Lu, Keyu Lv, Miao Jiang, Chao Fang#, Yi Wu#, Aizhen Yang#. Endoplasmic reticulum protein 29 negatively regulates platelet function and thrombosis in mice. Thrombosis Journal. 2025 May 7;23(1):44.
4. Zhenzhen Zhao*#, Yaqiong Zhang*, Yixin Cheng, Xuyang Chen, Yi Lu, Yue Han, Yi Wu# and Aizhen Yang#. Transmembrane thiol isomerase TMX1 inhibits fibrin formation by down-regulation of platelet phosphatidylserine exposure. Cell Communication and Signaling. 2025 May 2;23(1):212.
5. Chao He*, Aizhen Yang*, Keyu Lv*, Yuxin Zhang, Zhenzhen Zhao, Yi Lu, Chao Fang, Yue Han, Depei Wu, Miao Jiang, Jingyu Zhang#, Yi Wu#. Thiol isomerase ERp18 enhances platelet activation and arterial thrombosis. Research and Practice in Thrombosis and Haemostasis. 2025 Feb 27;9(2):102706.
6. Fengwu Chen*#, Aizhen Yang*, Yue Lu*, Yuxin Zhang, Jingyu Zhang, Jianan Bu, Runlin Guo, Yue Han, Depei Wu#, Yi Wu#. Differential transport pathways of saturated and unsaturated fatty acid esters in male mouse hepatocytes. Nature Communications. 2025 Feb 4;16(1):1344.
7. Zhenzhen Zhao*#, Yucan Wang*, Aizhen Yang*, Yi Lu, Xiaofeng Yan, Meinan Peng, Yue Han, Chao Fang, Depei Wu#, Yi Wu#. A novel role for thioredoxin-related transmembrane protein TMX4 in platelet activation and thrombus formation. J Thromb Haemost. 2025 Jan;23(1):277-292.
8. A Yang*, L Lin, J Zhang, Y Wu, Z Zhao#. A novel role for endoplasmic reticulum protein ERp72 in the pathogenesis of autoantibody-induced arthritis. Scand J Rheumatol. 2025 Jan;54(1):16-24.
9. Chao He*, Aizhen Yang*#, Yuxin Zhang, Zhenzhen Zhao, Yi Lu, Jingyu Zhang and Yi Wu#. A novel role for protein disulfide isomerase ERp18 in venous thrombosis. Thrombosis Journal. 2024 Dec 18;22(1):110.
10. Zhenzhen Zhao*#, Yixin Cheng, Yaqiong Zhang, Meinan Peng, Yue Han, Depei Wu, Aizhen Yang#, Yi Wu#. Transmembrane thiol isomerase TMX1 counterbalances the effect of ERp46 to inhibit platelet activation and integrin αIIbβ3 function. Research and Practice in Thrombosis and Haemostasis. 2024 Jul 22;8(5):102524.
11. Yaqiong Zhang*#, Aizhen Yang*, Zhenzhen Zhao#, Fengwu Chen, Xiaofeng Yan, Yue Han, Depei Wu, Yi Wu#. Protein disulfide isomerase is essential for spermatogenesis in mice. JCI Insight. 2024;9(12):e177743.
12. Liang Gao*, Chao He*, Aizhen Yang*#, Haibin Zhou, Qingxian Lu#, Raymond B. Birge, Yi Wu#. Receptor tyrosine kinases Tyro3, Axl, and Mertk differentially contribute to antibody-induced arthritis. Cell Communication and Signaling. 2023 Aug 3;21(1):195.
13. Yang A, Zhou J, Wang B, Dai J, Colman RW, Song W, Wu Y. A critical role for plasma kallikrein in the pathogenesis of autoantibody-induced arthritis. FASEB J. 2017 Dec;31(12):5419-5431.
14. Yang A, Xie Z, Wang B, Colman RW, Dai J, Wu Y. An essential role of high-molecular-weight kininogen in endotoxemia. J Exp Med. 2017 Sep 4;214(9):2649-2670.
15. Yang A, Chen F, He C, Zhou J, Lu Y, Dai J, Birge RB, Wu Y. The procoagulant activity of apoptotic cells is mediated by interaction with Factor XII. Front Immunol. 2017 Sep 25;8:1188.
16. Yang A, Dai J, Xie Z, Colman RW, Wu Q, Birge RB, Wu Y. High molecular weight kininogen binds phosphatidylserine and opsonizes urokinase plasminogen activator receptor-mediated efferocytosis. J Immunol. 2014 May 1;192(9):4398-4408.