Education Background：

2005~2009 Beijing Institute of Technology
Bioengineering, Bachelor
2009~2015 Peking University
Physiology, PhD, Mentor: Professor Shi-Qiang Wang

Work Experience：

2015~2019 New York University Langone Medical Center, Postdoctoral Research Fellow, Mentor: Professor William Coetzee
2019~2020 New York University Langone Medical Center, Research Assistant Professor, Assistant Director of Electrophysiology Core
2021~now Cyrus Tang Medical Institute, Soochow University
Professor, PhD supervisor

Research Direction:

The Cardiovascular Electrophysiology Research Group uses patch clamp techniques to study the function of ion channels in the cardiovascular system and related cardiovascular diseases. The main research directions include:
1) Identification of novel ion channels and their in vivo functions.
2) Gene therapy of cardiac ion channelopathy.
3) ATP-sensitive potassium channel in cardioprotection.

Representative Publication：(* corresponding author, # equal contribution)

1. Yang B, Xu T, Yang Q, Mo L, Huo J, Mu T, Zhi Y, Du Y, Wang H, Guo L, Zhu Z, Feng Y, Rui Y, Zhu L*, Coetzee WA*, Gao Q*, Yang HQ*. Proc Natl Acad Sci U S A. 2026.
2. Zhi Y, Yang B, Huo J, Wang H, Yang B, Zhou YF*, Xiao F*, Yang HQ*. Tyrosine phosphorylation of Kir6.2 subunit negatively regulates cardiac KATP channel activity. Basic Res Cardiol. 2025 Jun;120(3):473-488.
3. Huo J, Mo L, Lv X, Du Y, Yang HQ*. Ion Channel Regulation in Caveolae and Its Pathological Implications. Cells. 2025 Apr 24;14(9):631.
4. Huo JY, Feng YL, Chen YT, Yang B, Zhi YT, Wang HJ, Yang HQ*. Caveolin-3 negatively regulates endocytic recycling of cardiac KATP channels. Am J Physiol Cell Physiol. 2023 Oct 1;325(4):C1106-C1118.
5. Yang B, Yao JL, Huo JY, Feng YL, Coetzee WA, Xu GY*, Yang HQ*. Rab35 GTPase positively regulates endocytic recycling of cardiac KATP channels. Channels (Austin). 2022 Dec;16(1):137-147.
6. Yang HQ, Echeverry FA, ElSheikh A, Gando I, Anez Arredondo S, Samper N, Cardozo T, Delmar M, Shyng SL, Coetzee WA*. Subcellular trafficking and endocytic recycling of KATP channels. Am J Physiol Cell Physiol. 2022 Jun 1;322(6):C1230-C1247.
7. Yang HQ#, Zhou P#, Wang LP#, Zhao YT, Guo YB, Xu, M, Wang SQ*. Compartmentalized β1-adrenergic signaling synchronizes excitation-contraction coupling without modulating individual Ca2+ sparks in healthy and hypertrophied cardiomyocytes. Cardiovasc Res. 2020 Nov 1;116(13):2069-2080.
8. Yang HQ, Martinez-Ortiz W, Hwang J, Fan X, Cardozo TJ, Coetzee WA*. Palmitoylation of the KATP channel Kir6.2 subunit promotes channel opening by regulating PIP2 sensitivity. Proc Natl Acad Sci U S A. 2020 May 12;117(19):10593-10602.
9. Yang HQ, Pérez-Hernández M, Sanchez Alonso JL, Shevchuk A, Gorelik J, Rothenberg E, Delmar M, Coetzee WA*. Ankyrin-G Mediates Targeting of both Na+ and KATP Channels to the Cardiac Intercalated Disc. eLife. 2020 Jan 14;9:e52373.
10. Yang HQ#, Wang LP#, Gong YY#, Fan XX#, Zhu SY#, Wang XT, Wang YP, Li LL, Xing X, Liu XX, Ji GS, Hou TT, Zhang Y, Xiao RP, Wang SQ*. β2-Adrenergic Stimulation Compartmentalizes β1 Signaling into Nanoscale Local Domains by Targeting the C-Terminus of β1-Adrenoceptors. Circ Res. 2019 Apr 26;124(9):1350-1359.

Academic Association：

1. Committee member of Chinese Association for Physiological Sciences
2. Committee member of Biophysical Society of China
3. Youth editor of Biophysics Reports